11^th World Summit on Epilepsy and Bipolar Disorders August 20-21, 2024 Montreal, Canada

Epilepsy in women presents unique considerations, particularly concerning hormonal fluctuations during menstruation, pregnancy, and menopause, which can affect seizure frequency. Antiepileptic drugs (AEDs) may interact with hormonal contraceptives, impacting effectiveness. Pregnancy requires careful management to balance seizure control and potential risks to the fetus from AEDs. Inborn errors of metabolism can lead to epilepsy, often presenting in infancy or childhood. Prompt diagnosis through genetic testing and metabolic evaluations is crucial for effective management and to prevent long-term complications.

The semiology of epilepsy refers to the observable signs and symptoms of seizures, such as motor movements, sensory experiences, or alterations in consciousness. Pathophysiology involves the underlying mechanisms leading to abnormal neuronal activity, including genetic factors, structural brain abnormalities, neurotransmitter imbalances, and synaptic deregulation.

Prevention and management of neurodegenerative disorders involve lifestyle interventions, such as regular exercise, a balanced diet, and cognitive stimulation, to reduce risk factors. Additionally, early diagnosis, medication, and therapeutic strategies aim to slow disease progression, alleviate symptoms, and enhance quality of life for individuals affected by conditions like Alzheimer's and Parkinson's disease.

Novel therapeutic strategies for epilepsy include non-pharmacological approaches like ketogenic diet, vagus nerve stimulation, and responsive neurostimulation. Advancements in gene therapy, targeted drug delivery systems, and precision medicine hold promise for personalized treatments. These approaches aim to enhance seizure control, minimize side effects, and improve overall quality of life for patients with epilepsy.

Epilepsy in children presents unique challenges due to developmental considerations and potential impacts on cognition and behavior. Treatment typically involves antiepileptic drugs tailored to the child's age and seizure type. Early intervention, comprehensive care, and support for both the child and their family are essential for optimal management and quality of life.

Prevention of epilepsy involves avoiding head injuries, managing underlying conditions, and minimizing risk factors like alcohol abuse. Management includes antiepileptic drugs, lifestyle modifications, and in some cases, surgery or neurostimulation therapies. Education, regular follow-ups, and support networks help individuals effectively manage their condition and improve overall quality of life.

Epilepsy therapeutics encompasses a range of treatments tailored to seizure type, frequency, and individual needs. Antiepileptic drugs are the mainstay, with newer options offering improved efficacy and tolerability. Other approaches include ketogenic diet, surgery, neurostimulation, and emerging therapies like gene therapy, aiming to enhance seizure control and quality of life.

Epilepsy can significantly impact daily life by affecting activities such as driving, employment, and social interactions. Seizures may lead to injury, memory difficulties, and emotional challenges, impacting relationships and independence. Fear of seizures can cause anxiety and restrict participation in certain activities, requiring ongoing management and support for individuals with epilepsy.

Epilepsy imitators are conditions that mimic seizures but have different underlying causes. These include syncope (fainting), psychogenic non-epileptic seizures (psychological origin), migraines, and movement disorders like tremors. Accurate diagnosis is crucial to avoid unnecessary treatment with antiepileptic drugs and ensure appropriate management of the underlying condition.

Chronic disorders are conditions that persist over time, often requiring long-term management and care. Neurological disorders affect the nervous system, including the brain, spinal cord, and nerves, leading to symptoms like pain, muscle weakness, and cognitive impairment. Examples include epilepsy, Alzheimer's disease, multiple sclerosis, and Parkinson's disease.

Seizure disorders, including epilepsy, are characterized by recurrent, unprovoked seizures resulting from abnormal electrical activity in the brain. Seizures vary in type and severity, ranging from brief lapses in awareness to convulsions. Management typically involves antiepileptic drugs, lifestyle modifications, and sometimes surgical interventions to control seizures and improve quality of life.

Pediatric epilepsy refers to epilepsy diagnosed in children. It presents unique challenges due to developing brains and varying seizure types. Treatment often involves antiepileptic drugs, tailored to the child's age and seizure characteristics. Early intervention, comprehensive care, and support for both the child and their family are crucial for optimal management.

Psychological disorders are conditions characterized by abnormal thoughts, emotions, or behaviors that cause distress or impairment in functioning. Examples include depression, anxiety disorders, schizophrenia, and bipolar disorder. Treatment may involve therapy, medication, or a combination of both, tailored to the individual's specific needs and circumstances.

Drug delivery to the epileptic brain is challenging due to the blood-brain barrier's restrictive nature. Innovative approaches, such as nanoparticles, liposomes, and implantable devices, aim to enhance drug delivery efficiency and target specific brain regions while minimizing systemic side effects. These advancements hold promise for improving seizure control and patient outcomes.

Animal models of epilepsy, such as rodents and zebra fish, play a crucial role in epilepsy research. These models help study seizure mechanisms, evaluate potential treatments, and understand the underlying pathophysiology. They provide valuable insights into epilepsy's complex nature and facilitate the development of novel therapeutic interventions for human patients.